I used the patches on a mare that had major tying up problems and it totally resolved the issue... For the cost I would definetely recommend giving them a try
I guess it depends on what you need it for. I ordered it for headshaking - it claims that it will CURE it - my horse wasn't cured but was better. I think I used 3 boxes of it and only paid for one box - I probably could have gotten my money back for the first box but I did see improvement so I left it alone. I will try it again this Spring. If you do order it now and your horse is hairy be sure to put a blanket on over top. They don't stick to a haired up horse very well.
Someone else I know said they used it for a bleeder and had good results.